Deluxe Lipodize 120ct (Eclipse) Weight Control

<--Ingredients

LIPODIZE™ is a revolutionary non-stimulant dietary supplement that provides the body with a unique blend of minerals, phosphates, and herbs in order to help promote metabolic functions associated with fatty acid oxidation. LIPODIZE is the first supplement to utilize SIMM™ (Simmondson). This unique herb derived from the jojoba fruit has been shown in animal studies to be a potent appetite regulator. LIPODIZE also utilizes the powerful herbal combination of Ashwagandha and Gum Gugul extract in order to promote thyroid production for the stimulation of metabolic rate. Another crucial component of metabolic rate during low calorie intake is the supplementation of phosphate. LIPODIZE utilizes Calcium, Potassium, and Sodium Phosphate in order to stimulate thyroid production during low calorie intake. The final combination of capsaicin, ginger, and allyl-garlic extract has been shown in animal and human studies to promote thermogenesis coupled with enhanced carbohydrate and fatty acid oxidation. In other words, LIPODIZE is sure to give you that extra edge needed to breakthrough any fat loss plateau. LIPODIZE is definitely the new smackdown supplement of sports nutrition industry. If your interested in losing fat weight than LIPODIZE is for you!!!!

Eclipse Deluxe LIPODIZE (Lipolytic Oxidizing Complex) is a non-stimulant complex designed to regulate appetite, stimulate metabolic rate, and promote thermogenesis. Deluxe LIPODIZE is a combination of Simmondsin, Phosphates, Ashwagandha, Gum Gugul extract, Allyl-Garlic extract, Capsaicin, and Ginger extract. Until recently, the most effective fat loss agents have been herbal stimulants such as Ma Huang and Guarana. These stimulants bind to beta 1 and 2 receptors, which control heart rate and blood pressure. Many people for various health reasons cannot ingest these compounds. Deluxe LIPODIZE is a revolutionary dietary supplement that provides the body with a unique blend of minerals, phosphates, and herbs in order to help promote the metabolic functions associated with fatty acid oxidation.

The first ingredient, Simmondson, is a glycosidic herbal extract of the jojoba plant. This compound has been shown in animal studies to regulate appetite via the cholecystokinin pathway.1 Cholecystokinin (CCK) is a peptide hormone released whenever fat enters the stomach from a portion of the small intestine. CCK then stimulates the gallbladder to release bile for the emulsification of fat. This process decreases gastric motility causing a delayed release from the stomach and small intestine. The decrease in gastric motility stimulates the vagus nerve and sends a message to the hypothalmus, which is the appetite control center of the brain. This instructs the body how long to stay full and thus control satiety. Simmondsin is thought to either directly stimulate CCK release or bind to the same receptors as CCK. Simmondsin may also increase brown adipose tissue and metabolic rate by stimulating thyroid production.1,2 Other mechanisms involved in the fat loss properties of Simmondsin include stimulation of thyroxin and growth hormone.3 Ashwagandha root is an ayurverdic herbal extract that exerts pharmacological effects via its free radical scavenging activity.4 Ashwagandha root has been shown in animal studies to significantly increase T3 thyroid, T4 thyroid, and glucose-6-phosphatase.5 Thyroid hormone is responsible for the control of our basal metabolic rate. (BMR) BMR is the amount of calories utilized to maintain weight at rest. Any increase in thyroid results in an increase in BMR and fat loss if a consistent amount of calories are ingested. Hypocaloric intake or low calories usually results in a decreased BMR via reduction of thyroid. This is a natural safety mechanism telling the body to stop losing weight. Ashwagandha attempts to promote thyroid production thus resulting in continued fat loss.

Another well-known ayurverdic herbal that exerts thyroid stimulating activity is Gum Guggulu (Commiphora mukul). Gugulipid is the standardized extract derived from the bark of the Mukul myrrh tree, a small, thorny tree native to India and Arabia. The main constituents of gugulipid are substances called guggulsterones. Both E-guggulsterone and Z-guggulsterone are believed to be the active ingredients. Interestingly enough, Guggulu has been shown in animal studies to stimulate T3 thyroid via similar free radical scavenging activity as Ashwagandha.6 Guggulu and Ashwagandha both caused a decrease in hepatic lipid peroxidation, which is the principal site of T3 generation.7 These two ayurverdic herbals should cause a synergistic effect upon T3 generation during any type of dieting phase in order to provide continual fat loss.

Mineral Phosphates have also been studied during hypocaloric intake due to their thyroid stimulating properties. The Phosphate Complex utilized in the research consists of Calcium, Potassium, and Sodium phosphate. Phosphates have the ability to stimulate thyroid production while ingesting a hypo caloric intake.8 It's thought that phosphate supplementation in obese patients on a low-energy diet enhances BMR irrespectively of the rate of weight loss. This effect seems to be, at least partly, due to an influence of phosphates on peripheral metabolism of thyroid hormones.9 In other words, the body's survival mechanism turns on when there is inadequate substrate for thyroid metabolism. So the phosphates trick the body into thinking there is more than adequate substrate for thyroid metabolism resulting in continual thyroid generation.

The promotion of non-stimulant thermogenesis is a noble but questionable task. Although, there are a few non-stimulant compounds that promote thermogenesis. Red pepper extract (Capsaicin), Ginger (Gingerols and Shoagols), and Ally-Garlic extract have all been shown to promote thermogenesis via the mild production of catecholamines. The Capsaicin and Ginger utilize similar pathways to stimulate thermogenesis. Capsaicin is an extract of red pepper that has the ability to promote dietary induced thermogenesis coupled with carbohydrate and fat oxidation.10 The capsaicin produces catecholamines and cAmp, which are involved in the process of lipolysis.11 When a dose of red pepper was given with a meal it significantly increased carbohydrate oxidation for over 2 hours after the meal.12 In another instance, when red pepper was given to a group of long distance runners with a meal they found that carbohydrate oxidation was significantly stimulated.13 Both studies confirmed that the actions of the red pepper were caused by beta-adrenergic stimulation. In other words, when red pepper is given with a meal it might have the ability to promote caloric expenditure. Since capsaicin performs its actions via beta-adrenergic stimulation it might appear that it could raise blood pressure and heart rate. Although, animal studies show capsaicin can only alter blood pressure if given in a high enough dose and allowed to enter the system at very fast rate.

Ginger is yet another spice that has shown thermogenic action. Actually, the pungent principles of ginger consisting of gingerols and shogaols are responsible for the thermogenic effect.14 These pungent principles utilize the same pathway as capsaicin. The synergistic combination of capsaicin and garlic should promote a noticeable non-stimulant thermogenic boost.

The Ally-Garlic extract has been shown in animal studies to induce thermogenesis by increasing uncoupling protein (UCP) in brown adipose tissue and promote the release of catecholamines.15 The administration of garlic disulfides without the allyl portion does not produce the same thermogenic properties. The increase of UCP in brown adipose tissue results in the promotion of metabolically active tissue. The increase in catecholamines works in conjunction with the ginger and capsaicin to produce a thermogenic response. In summary, Deluxe LIPODIZE (Lipolytic Oxidizing Complex) attacks the three most crucial aspects of fat loss. These aspects include appetite regulation, thyroid maintenance, and thermogenesis. This unique non-stimulant formula provides an effective alternative to (E-C-A) stimulant stacks. Deluxe LIPODIZE has set a new standard in non-stimulant fat loss. Eclipse Deluxe LIPODIZE (Lipolytic Oxidizing Complex) is yet another Cutting Edge Concepts original formula that is sure to attract a wide range of consumers concerned with non-stimulant fat loss.

REFERENCES 1. Flo, G. et al. 1999. "Effects of simmondsin on food intake, growth, and metabolic variables in lean and obese zucker rats" Br J Nutr; 81: p.159-167. 2. Flo, G. et al. 1998. "Comparison of the effects of simmondsin and cholecystokinin on metabolism, brown adipose tissue and the pancreas in food-restricted rats" Horm Metab Res. Aug; 30(8): p.504-508. 3. Arnouts, S. et al. 1993. "Jojoba meal (Simmondsia chinensis) in the diet of broiler breeder pullets: physiological and endocrinological effects" Poult Sci. Sep; 72(9): p.1714-1721. 4. Panda, S., Kar, A. et al. 1998. "Changes in thyroid hormone concentrations after administration of ashwaganda root extract to adult mice" J Pharm Pharmacol. Sep; 50(9): p. 1065-1068. 5. Panda, S., Kar, A. et al. 1997. "Evidence for free radical scavenging activity of Ashwagandha root powder in mice" Indian J Physiol Pharmacol. Oct; 41(4): p.424-426. 6. Panda, S., Kar, A. et al. 1997. “Gugulu (Commiphora mukul) induces triiodothyronine production: possible involvement of lipid peroxidation” Life Sci. 1999; 65(12): PL137-41. 7. Tripathi, YB. et al.“Thyroid stimulating action of Z-guggulsterone obtained from Commiphora mukul” Planta Med. 1984 Feb; (1): 78-80. 8. Kaciuba-Uscilka, H. et al. 1993. "Effect of phosphate supplementation on metabolic and neuroendocrine responses to exercise and oral glucose load in obese women during weight reduction" J Physiol Pharmacol. Dec; 44(4): p.425-440. 9. Nazar, K. et al. 1996. "Phosphate supplementation prevents a decrease of triiodothyronine and increases resting metabolic rate during low energy diet" J Phys Pharm. 47: p.373-383. 10. Dullo, AG. 1998. "Spicing fat for combustion" Invited Commentary. Br J Nutr; 80: p.493-494. 11. Mayumi, Y. et al. 1998. "Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women" Br J Nutr. 80: p.503-510. 12. Yoshioka, M. et al. 1995. "Effects of red-pepper diet on the energy metabolism in men" J Nutr Sci Vitaminol. Dec; 41(6): p.647-656. 13. Lim, K. et al. 1997. "Dietary red pepper ingestion increases carbohydrate oxidation at rest and during exercise in runners" Med Sci Sports Exerc. Mar; 29(3): p.355-361. 14. Eldershaw, TP. et al. 1992. "Pungent principles of Ginger (Zingiber officinale) are thermogenic in the perfused rat hindlimb" Int J Obes Relat Metab Disord. Oct; 16(10): p.755-763. 15. Yuriko, Oi. et al. 1999. "Allyl-Containing Sulfides in Garlic Increase Uncoupling Protein Content in Brown Adipose Tissue, and Noradrenaline and Adrenaline Secretion in Rats" J Nutr. 129(2):p. 336-342.